Table 5.
Adjusted difference () in lipid outcome in offspring at 3 months and 18 months of age for 1-unit (ng/mL) increase in maternal pregnancy serum PFAA concentration obtained from linear regression models.
| Compound (ng/mL) | Total cholesterol SDS | LDL SDS | HDL SDS | Triglyceride SDS | ||||
|---|---|---|---|---|---|---|---|---|
| (95% CI) | (95% CI) | (95% CI) | (95% CI) | |||||
| PFHxS | ||||||||
| 3 monthsa | (, 0.17) | 0.54 | 0.01 (, 0.26) | 0.93 | (, 0.18) | 0.55 | 0.18 (, 0.44) | 0.16 |
| 18 monthsb | (, 0.21) | 0.68 | (, 0.22) | 0.65 | 0.02 (, 0.27) | 0.89 | (, 0.04) | 0.09 |
| PFOS | ||||||||
| 3 monthsa | 0.01 (, 0.04) | 0.66 | 0.02 (, 0.05) | 0.41 | 0.003 (, 0.04) | 0.89 | (, 0.02) | 0.50 |
| 18 monthsb | 0.02 (, 0.08) | 0.60 | 0.04 (, 0.10) | 0.28 | (, 0.02) | 0.26 | 0.001 (, 0.07) | 0.99 |
| PFOA | ||||||||
| 3 monthsa | (, 0.03) | 0.14 | (, 0.08) | 0.65 | (, 0.04) | 0.22 | (, 0.08) | 0.61 |
| 18 monthsb | 0.07 (, 0.22) | 0.32 | 0.04 (, 0.20) | 0.63 | (, 0.09) | 0.48 | 0.10 (, 0.26) | 0.19 |
| PFNA | ||||||||
| 3 monthsa | (, 0.13) | 0.30 | (, 0.23) | 0.67 | (, 0.26) | 0.78 | (, 0.20) | 0.52 |
| 18 monthsb | 0.37 (, 0.79) | 0.08 | 0.24 (, 0.70) | 0.29 | (, 0.40) | 0.98 | 0.18 (, 0.63) | 0.41 |
| PFDA | ||||||||
| 3 monthsa | (, 0.43) | 0.49 | (, 0.62) | 0.87 | 0.004 (, 0.69) | 0.99 | (, 0.47) | 0.55 |
| 18 monthsb | 1.06 (0.08, 2.03) | 0.03 | 0.64 (, 1.71) | 0.24 | (, 0.83) | 0.79 | 0.92 (, 1.95) | 0.08 |
Note: CI, confidence interval; HDL, high-density lipoprotein cholesterol; LDL, low-density lipoprotein cholesterol; PFDA, perfluorodecanoic acid; PFHxS, perfluorohexane sulfonic acid; PFNA, perfluorononanoic acid; PFOA, perfluorooctanoic acid; PFOS, perfluorooctane sulfonic acid; SDS, standard deviation scores.
Adjusted for maternal age, parity, prepregnancy BMI, prepregnancy , educational level, smoking, and sex ( for total cholesterol SDS, HDL SDS, and triglyceride SDS; and for LDL SDS).
Adjusted for maternal age, parity, prepregnancy BMI, prepregnancy , educational level, smoking, sex, and lipid outcome at age 3 months ( for all markers of lipid metabolism).