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. 2020 Jun 10;12(7):e12088. doi: 10.15252/emmm.202012088

Figure EV5. Related to Fig 6. BAM15 restricts adipose tissue expansion and lipid deposition to liver and kidney in C57BL/6J mice.

Figure EV5

  • A, B
    (A) Circulating adiponectin (N = 6 per group) and (B) beta‐hydroxybutyrate (BHB) (CTRL N = 7, BAM15 N = 8) concentrations in CTRL‐ and BAM15‐treated animals.
  • C
    Fatty acid oxidation attributable to acid‐soluble metabolites (ASM) in mixed gastrocnemius muscle ± 1 mM pyruvate (N = 7 per group).
  • D, E
    (D) Ex vivo rates of glycerol release from iWAT and (E) gWAT in CTRAL‐ and BAM15‐treated animals (N = 8 per group).
  • F
    Representative immunoblots of p‐AMPKT172 and AMPK from heart and liver homogenates and p‐ACCS79 and ACC from mixed gastrocnemius muscle.
Data information: Data are shown as the mean ± SEM. Main effects of treatment × time were assessed by two‐way repeated‐measures ANOVA with Tukey's post hoc test. Main effects of treatment alone were assessed by unpaired Student's t‐test. Source data are available online for this figure.