Table 2.
Detailed characteristics of the metastatic biliary tract cancer patients (n = 14)
| Patients | Biliary tract cancer subtype | Age at initial diagnosis | Age at Nal-IRI initiation | Toxicity | Pre-treatment regimens in metastatic setting | Nal-IRI line | Therapy response |
|---|---|---|---|---|---|---|---|
| 1. Female | Intrahepatic CCC | 51.7 | 53.9 |
Diarrhea grade 2 Fatigue grade 1 Nausea grade 1 Oral mucositis grade 1 |
1st line: gemcitabine + cisplatin 2nd line: gemcitabine + nab-paclitaxel |
3rd | PR |
| 2. Female | Intrahepatic CCC | 60.3 | 60.7 | Nausea grade 1 | 1st line: gemcitabine + cisplatin | 2nd | PR |
| 3. Female | Intrahepatic CCC | 78.8 | 79.3 |
Diarrhea grade 1 Neutropenia grade 3 |
1st line: gemcitabine + cisplatin | 2nd | PR |
| 4. Male | Intrahepatic CCC | 54.5 | 54.9 | Diarrhea grade 1 | 1st line: gemcitabine + cisplatin | 2nd | PR |
| 5. Male | Intrahepatic CCC | 70.6 | 73.6 |
Diarrhea grade 1 Fatigue grade 1 Nausea grade 1 |
1st line: gemcitabine + cisplatin 2nd line: capecitabine + nab-paclitaxel |
3rd | PR |
| 6. Male | Extrahepatic CCC | 73.5 | 74.1 | No toxicities reported | 1st line: gemcitabine + nab-paclitaxel | 2nd | PR |
| 7. Female | Intrahepatic CCC | 32.7 | 43.6 |
Neutropenia grade 1 Thrombopenia grade 1 |
1st line: gemcitabine + cisplatin 2nd line: capecitabine + irinotecan 3rd line: capecitabine + nab-paclitaxel |
4th | SD |
| 8. Female | Intrahepatic CCC | 64.0 | 64.8 | Fatigue grade 2 |
1st line: gemcitabine + oxaliplatin 2nd line: capecitabine + nab-paclitaxel |
3rd | PD |
| 9. Female | Intrahepatic CCC | 54.9 | 57.7 | Neutropenia grade 1 |
1st line: gemcitabine + nab-paclitaxel 2nd line: capecitabine + oxaliplatin 3rd line: regorafenib 4th line: nintedanib |
5th | PD |
| 10. Female | Intrahepatic CCC | 60.4 | 60.9 | Diarrhea grade 1 | 1st line: gemcitabine + cisplatin | 2nd | PD |
| 11. Female | Intrahepatic CCC | 75.9 | 77.5 | Anemia grade 1 |
1st line: Gemcitabine + Cisplatin 2nd line: 5-fluorouracil + folinic acid 3rd line: gemcitabine + nab-paclitaxel |
4th | PD |
| 12. Female | Intrahepatic CCC | 53.5 | 54.6 | Neutropenia grade 3 |
1st line: gemcitabine + cisplatin 2nd line: gemcitabine + nab-paclitaxel |
3rd | PD |
| 13. Female | Intrahepatic CCC | 56.4 | 57.3 |
Nausea grade 1 Anemia grade 1 |
1st line: gemcitabine + cisplatin | 2nd | PD |
| 14. Male | Intrahepatic CCC | 58.3 | 59.4 |
Nausea grade 2 Oral mucositis grade 1 |
1st line: gemcitabine + cisplatin 2nd line: capecitabine + oxaliplatin |
3rd | PD |