Fig. 3.

Progression of tau pathology across different spatial patterns. We used the means and standard deviations of Aβ− individuals with entorhinal tau < 1.2 to identify individuals with high tau in the different spatial patterns. The patterns that were determined to show increased binding in a greater number of participants were considered to be regions of early tau deposition. Using this approach, we found a spreading order of tau across the spatial patterns from limbic and ventral areas, to lateral and medial posterior regions, and frontal and sensorimotor cortices. Patterns colored in light red correspond to a newly added stage, whereas patterns colored in dark red correspond to previous stage