Table 3.
Association between Inferred Haplotypes of the WTAP Gene and Hepatoblastoma Risk
| Haplotypesa | Cases (n = 620) |
Controls (n = 2,886) |
Crude OR (95% CI) | p | Adjusted ORb (95% CI) | pb |
|---|---|---|---|---|---|---|
| No. (%) | No. (%) | |||||
| GAT | 113 (18.23) | 530 (18.36) | 1.00 | 1.00 | ||
| GAG | 180 (29.03) | 922 (31.95) | 0.92 (0.71–1.19) | 0.504 | 0.92 (0.71–1.19) | 0.502 |
| GGT | 95 (15.32) | 486 (16.84) | 0.92 (0.68–1.24) | 0.570 | 0.91 (0.68–1.23) | 0.557 |
| GGG | 119 (19.19) | 423 (14.66) | 1.32 (0.99–1.76) | 0.059 | 1.32 (0.99–1.76) | 0.059 |
| AAT | 30 (4.84) | 206 (7.14) | 0.68 (0.44–1.05) | 0.085 | 0.69 (0.44–1.06) | 0.088 |
| AAG | 35 (5.65) | 105 (3.64) | 1.56 (1.01–2.41) | 0.043 | 1.57 (1.02–2.43) | 0.041 |
| AGT | 4 (0.65) | 3 (0.10) | 6.25 (1.38–28.29) | 0.018 | 6.10 (1.35–27.69) | 0.019 |
| AGG | 44 (7.10) | 211 (7.31) | 0.98 (0.67–1.44) | 0.910 | 0.98 (0.67–1.44) | 0.912 |
The results were in bold if the 95% confidence intervals (CIs) excluded 1, or p values were less than 0.05. OR, odds ratio; No., number.
a
The haplotypes’ order was rs9457712, rs1853259, and rs7766006.
b
Obtained in logistic regression models with adjustment for age and gender.