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Frequencies of indels and apparent substitutions in WT and LIG4−/− HeLa cells. (a) Experimental scheme. (b), (c) Bar graphs showing the frequencies of insertion (blue), deletion (red), and MMEJ-mediated deletion (orange) at eight endogenous targets in WT and LIG4−/− cells (n = 1). (d) Apparent substitution frequencies in the WT-length groups. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
