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. Author manuscript; available in PMC: 2020 Jul 7.
Published in final edited form as: Compr Physiol. 2019 Dec 18;10(1):125–170. doi: 10.1002/cphy.c190011

Figure 5. Simplified overview of factors contributing to sex/gender differences and sexual dimorphism in PAH and PH.

Figure 5

Note that significant cross talk exists between the factors and mediators listed in this figure. BMPR2, gene encoding bone morphogenic protein receptor 2; CYP1B1, gene encoding cytochrome P450 1B1; CYP19A1, gene encoding aromatase; DHEA, dehydroepiandrosterone; ESR1, gene encoding estrogen receptor α; SNP, single-nucleotide polymorphism.