Fig. 1.

Higher levels of FUT4 is associated with poor prognosis in lung adenocarcinoma. (a) Heatmap of RNA-seq transcriptomic analysis for eight α-(1,3)-fucosyltransferases in surgically-resected lung cancer tissues at National Taiwan University Hospital (LUAD, N = 44, and LUSC, N = 37) and from TCGA database (LUAD, N = 517, and LUSC, N = 502), respectively. LUAD: lung adenocarcinoma. LUSC: lung squamous cell carcinoma. (b) Relationships between expression levels of individual fucosyltransferases and overall survival in patients with lung adenocarcinoma. (N = 428, High vs. Low expressions, cutoff=median; Cox proportional hazard models) (c,d) Kaplan-Meier curves of overall survival for patients with lung adenocarcinoma (LUAD) (c) or squamous cell carcinoma (LUSC) (d). Patients were divided into two groups based on the median value of FUT4 expressions. (e) The correlation matrix of all members in the FUT family based on the RNA-seq data of the TCGA lung adenocarcinoma samples. Numbers in the colored boxes represent Pearson correlation coefficients. Red and blue colors denote positive and negative correlations with statistical significance (p < 0.05), respectively. (f) mRNA levels of FUT4 in lung adenocarcinoma tissues compared to those of paired adjacent unaffected tissues from National Taiwan University Hospital (N = 75). Data information: p value in (b–d) was calculated by the log-rank test, and in (f) was calculated by Wilcoxon matched-pairs signed-rank test.