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. 2020 Jun 20;23(7):101301. doi: 10.1016/j.isci.2020.101301

Table 1.

H-Bond and π – π Interactions of Ligands of All Crystal Structures of CB₁ and CB₂

			CB1				CB2
PDB Code	5XR8	5XRA	6N4B	5TGZ	5U09	6KPC	6PT0	5ZTY
Ligand	AM841	AM11542	FUB	AM6538	Taranabant	AM12033	WIN 55,212-2	AM10257
Binding affinity Ki (nM)	1.14	0.11	0.098	0.038	0.13	0.37	3.3	0.61
Hydrogen bond	S383^7.39	S383^7.39	S383^7.39			Ser285^7.39
	I267^ECL2		H178^2.65					S165^4.57
	Y275^5.39
π – π interaction			W279^5.43			F94^2.64	F94^2.64
	F170^2.57	F170^2.57	F170^2.57	F170^2.57		F183^ECL2		F183^ECL2
	F268^ECL2	F268^ECL2	F268^ECL2	F268^ECL2		F281^7.35
	F379^7.35	F379^7.35		F102^N-term			F91^2.61
	F189^3.25	F189^3.25		W356^6.48			F117^3.36	F117^3.36
	F177^2.64	F177^2.64					W258^6.48	W258^6.48
Reference	(Hua et al., 2017)	(Hua et al., 2017)	(Krishna Kumar et al., 2019)	(Hua et al., 2016)	(Shao et al., 2016)	(Hua et al., 2020)	(Xing et al., 2020)	(Li et al., 2019)