Table 3.

Binding of THC, CBD, AEA, and 2-AG at the Various Potential Pockets on CB₁

Modulators	Pocket 1	Pocket 2	Pocket 3	Orthosteric Site
	ΔG (kcal/mol)	ΔG (kcal/mol)	ΔG (kcal/mol)	ΔG (kcal/mol)
THC				−8.34
CBD	−7.75	–	−7,39	−8.15
AEA				−9.55
2-AG				−9.41