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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Adv Exp Med Biol. 2020;1223:155–165. doi: 10.1007/978-3-030-35582-1_8

Fig.3. Tumor expressed CD200 inhibits the expansion of myeloid cells in TME.

Fig.3.

Cancer cells are known to recruit myeloid cells to the tumor microenvironment through the secretion of myeloid cell growth factors such as M-CSF-1. When the CD200-CD200R axis is intact (left panel), tumor expressed CD200 can inhibit myeloid cell expansion via interaction with CD200R. In the absence of CD200-CD200R interaction (right panel), significant expansion of myeloid cells occur. However, the types of myeloid cells that expand may depend on available factors driving myeloid cell differentiation in the tumor microenvironment.