Figure 3.

Collagen Content of Glandular or Stromal Components of Transition Zone Biopsy Specimens. If present, glandular (>2 epithelial ducts/field) or stromal (≤2 epithelial ducts/field) components of TZ biopsy specimens were evaluated for collagen content. A. Dot plot of percent total collagen content of glandular components of 36 biopsy specimens from 35 trial participants who exhibited clinical progression and 35 who did not (mean collagen, 21.5%); and of stromal components of biopsies from 39 men who exhibited clinical progression (mean collagen, 28.5%) and 36 who did not (groups as delineated in Table 1). The percent total collagen content of biopsies exhibiting stromal histology was significantly higher (p<0.0001) than those exhibiting glandular histology. B. Box and whisker plots of total collagen content averaged from glandular and stromal components of left and right TZ biopsy specimens from trial participants exhibiting clinical progression (gray boxes) or not (white boxes). Lower extreme, lower quartile, median (line), mean (+), upper quartile and upper extremes are indicated. The total collagen content of TZ biopsy specimens exhibiting glandular or stromal histology from trial participants demonstrating clinical progression was significantly higher (glandular, p<0.05 and stromal, p<0.01) than those who did not. C, D. Box and whisker plots of the total collagen content of glandular components (C) and stromal components (D) of TZ biopsy specimens from trial participants in each treatment group who demonstrated progression (gray boxes) or not (white boxes). The collagen content of biopsy specimens from the doxazosin+finsteride treatment group was significantly higher for men who demonstrated clinical progression than those who did not in both the glandular and stromal tissues (p<0.05).