Table 1.

Putative urinary biomarkers of hormone treatment in the prostate; urine changes determined via RM-ANOVA with Tukey’s post-hoc test, prostate changes determined via Student’s t-test with permutation-based FDR = 0.15.

			Prostate changes	Urine changes
Entry	Protein name	Gene name	week 8 treated:control	est. change between the significant time points	refer to:
P70269	Cathepsin E	Ctse	>10	down ~3x at week 8	Fig. S-1
P20060	Beta-hexosaminidase subunit beta	Hexb	4.4	up ~2x at week 8	Table S-1
P46412	Glutathione peroxidase 3	Gpx3	4.1	up, detectable after week 0	Fig. 3
P23953	Carboxylesterase 1C	Ces1c	3.4	up >10x at week 8	Fig. S-1
P09036	Serine protease inhibitor Kazal-type 1	Spink1	3.3	up ~4x after week 0	Fig. S-1
Q91XE4	N-acyl-aromatic-L-amino acid amidohydrolase	Acy3	3.1	up, detectable at week 8	Fig. S-1
P21614	Vitamin D-binding protein	Gc	3.0	up ~5x at week 8	Table S-1
P97449	Aminopeptidase N	Anpep	2.9	up ~8x at weeks 4 and 8	Fig. S-3
Q8CIF4	Biotinidase	Btd	2.6	up >10x at weeks 2 and 8	Table S-1
Q60928	Glutathione hydrolase 1 proenzyme	Ggt1	2.3	up >10x after week 0	Fig. 3
P70699	Lysosomal alpha-glucosidase	Gaa	2.3	up ~6x at week 4	Table S-1
P07724	Serum albumin	Alb	2.0	up ~3x at weeks 4 and 8	Fig. S-2
P00920	Carbonic anhydrase 2	Ca2	0.3	down >10x at week 8	Table S-1
Q00898	Alpha-1-antitrypsin 1–5	Serpina1e	0.2	down, not detected after week 0	Fig. S-1
Q9D154	Leukocyte elastase inhibitor A	Serpinb1a	0.2	up; detectable after week 8	Fig. S-1