Table 1.
Putative urinary biomarkers of hormone treatment in the prostate; urine changes determined via RM-ANOVA with Tukey’s post-hoc test, prostate changes determined via Student’s t-test with permutation-based FDR = 0.15.
| Prostate changes | Urine changes | ||||
|---|---|---|---|---|---|
| Entry | Protein name | Gene name | week 8 treated:control | est. change between the significant time points | refer to: |
| P70269 | Cathepsin E | Ctse | >10 | down ~3x at week 8 | Fig. S-1 |
| P20060 | Beta-hexosaminidase subunit beta | Hexb | 4.4 | up ~2x at week 8 | Table S-1 |
| P46412 | Glutathione peroxidase 3 | Gpx3 | 4.1 | up, detectable after week 0 | Fig. 3 |
| P23953 | Carboxylesterase 1C | Ces1c | 3.4 | up >10x at week 8 | Fig. S-1 |
| P09036 | Serine protease inhibitor Kazal-type 1 | Spink1 | 3.3 | up ~4x after week 0 | Fig. S-1 |
| Q91XE4 | N-acyl-aromatic-L-amino acid amidohydrolase | Acy3 | 3.1 | up, detectable at week 8 | Fig. S-1 |
| P21614 | Vitamin D-binding protein | Gc | 3.0 | up ~5x at week 8 | Table S-1 |
| P97449 | Aminopeptidase N | Anpep | 2.9 | up ~8x at weeks 4 and 8 | Fig. S-3 |
| Q8CIF4 | Biotinidase | Btd | 2.6 | up >10x at weeks 2 and 8 | Table S-1 |
| Q60928 | Glutathione hydrolase 1 proenzyme | Ggt1 | 2.3 | up >10x after week 0 | Fig. 3 |
| P70699 | Lysosomal alpha-glucosidase | Gaa | 2.3 | up ~6x at week 4 | Table S-1 |
| P07724 | Serum albumin | Alb | 2.0 | up ~3x at weeks 4 and 8 | Fig. S-2 |
| P00920 | Carbonic anhydrase 2 | Ca2 | 0.3 | down >10x at week 8 | Table S-1 |
| Q00898 | Alpha-1-antitrypsin 1–5 | Serpina1e | 0.2 | down, not detected after week 0 | Fig. S-1 |
| Q9D154 | Leukocyte elastase inhibitor A | Serpinb1a | 0.2 | up; detectable after week 8 | Fig. S-1 |