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. 2020 Jun 30;11:1151. doi: 10.3389/fimmu.2020.01151

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Copyright © 2020 Mayer, Preuss, Grottenthaler, Berg and Klein.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Carbachol-induced [Ca²⁺] signal in the mAchR3 functional assay (A) and proliferation (B) of cholangiocytes (TFK-1 cells) constitutively expressing mAChR3 after incubation of immunoglobulins from PBC patients before therapy and in the follow-up (a) without any therapy, (b) during therapy with UDCA, (c) during therapy with immunosuppressive therapy. Data are given as percentage of RLUs (A) or counts per minute (cpm) (B) w/o incubation with immunoglobulins. –, median; gray, normal range; n.s., not significant.