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. 2020 Jun 30;8:537. doi: 10.3389/fcell.2020.00537

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Copyright © 2020 Efimova, Zakharova and Ostroumova.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of alkaloids on the steady-state transmembrane current flowing through membranes modified by CecA (A–C) and Nys (D–F). The moment of the addition of 0.4 mM piperine (A,D), dihydrocapsaicin (B,E), and capsaicin (C,F) to the bilayer bathing solution is indicated by an arrow. The lipid bilayers were composed of DOPS/DOPE (50/50 mol%) and bathed in 0.1 M KCl, pH 7.4 (A–C) or POPC/Chol (67/33 mol%) and bathed in 2.0 M KCl, pH 7.4 (D–F). V = 50 mV. Inserts: Current fluctuations of single CecA channels.