Table 1.
Antibiotic resistance patterns of Klebsiella pneumoniae clinical isolates from five hospitals
| Antibiotics | Total samples |
ESBL-positive (30 isolates) | ESBL-negative (58 isolates) | p value∗ | ||
|---|---|---|---|---|---|---|
| Resistance | Intermediate | Sensitive | ||||
| Amoxicillin/clavulanic acid | 26 (29.5%) | 8 (9.0%) | 54 (61.3%) | 12 (40.0%) | 14 (24.1%) | 0.02 |
| Ceftazidime | 34 (38.6%) | 2 (2.2%) | 52 (59.0%) | 23 (76.6%) | 11 (18.9%) | < 0.001 |
| Cefotaxime | 37 (42.0%) | 1 (1.1%) | 50 (56.8%) | 22 (73.3%) | 15 (25.8%) | < 0.001 |
| Cefepime | 22 (25.0%) | 1 (1.1%) | 65 (73.8%) | 14 (46.6%) | 8 (13.7%) | < 0.001 |
| Ceftriaxone | 40 (45.4%) | 4 (4.5%) | 44 (50.0%) | 22 (73.3%) | 18 (31.0%) | < 0.001 |
| Aztreonam | 38 (43.1%) | 2 (2.2%) | 48 (54.5%) | 21 (70.0%) | 17 (29.3%) | < 0.001 |
| Ertapenem | 11 (12.5%) | 5 (5.6%) | 72 (81.8%) | 4 (13.3%) | 7 (12.0%) | 0.10 |
| Imipenem | 10 (11.3%) | 3 (3.4%) | 75 (85.2%) | 6 (20.0%) | 4 (6.8%) | 0.01 |
| Norfloxacin | 27 (30.6%) | 1 (1.1%) | 60 (68.1%) | 10 (33.3%) | 17 (29.3%) | 0.11 |
| Levofloxacin | 19 (21.5%) | 1 (1.1%) | 68 (77.2%) | 7 (23.3%) | 12 (20.6%) | 0.13 |
| Nalidixic acid | 33 (37.5%) | 11 (12.5%) | 44 (50.0%) | 13 (43.3%) | 20 (34.4%) | 0.06 |
| Ofloxacin | 23 (26.1%) | 5 (5.6%) | 60 (68.1%) | 9 (30.0%) | 14 (24.1%) | 0.06 |
| Ciprofloxacin | 23 (26.1%) | 1 (1.1%) | 64 (72.7%) | 9 (30.0%) | 14 (24.1%) | 0.05 |
| Amikacin | 18 (20.4%) | 2 (2.2%) | 68 (77.2%) | 13 (43.3%) | 5 (8.6%) | < 0.001 |
| Tetracycline | 25 (28.4%) | 1 (1.1%) | 62 (70.4%) | 9 (30.0%) | 16 (27.5%) | 0.12 |
| Gentamicin | 24 (27.2%) | 2 (2.2%) | 62 (70.4%) | 16 (53.3%) | 8 (13.7%) | < 0.001 |
| Tobramycin | 24 (27.2%) | 2 (2.2%) | 62 (70.4%) | 16 (53.3%) | 8 (13.7%) | < 0.001 |
| Streptomycin | 38 (43.1%) | 3 (3.4%) | 47 (53.4%) | 20 (66.6%) | 18 (31.0%) | < 0.001 |
| Kanamycin | 29 (32.9%) | 4 (4.5%) | 55 (62.5%) | 15 (50.0%) | 14 (24.1%) | < 0.001 |
| Neomycin | 5 (5.6%) | 5 (5.6%) | 78 (88.6%) | 2 (6.6%) | 3 (5.1%) | 0.15 |
| Co-trimoxazole | 46 (52.2%) | 0 (0.0%) | 42 (47.7%) | 18 (60.0%) | 28 (48.2%) | 0.10 |
Abbreviation: ESBL, extended-spectrum β-lactamase.
∗
Value of p is for a comparison of resistance among ESBL-producers with that among non-producers.