TABLE 2.
ORs and 95% CIs for the risk of cognitive impairment according to TIMP‐1 quartiles
| Variable | TIMP‐1, ng/mL | P Value for Trend |
Each SD (0.17 ng/mL) Increase in Logarithm TIMP‐1 |
|||
|---|---|---|---|---|---|---|
| <154.4 | 154.4‐185.7 | 185.7‐220.6 | ≥220.6 | |||
| Median | 136.7 | 168.2 | 199.5 | 259.9 | — | — |
| Cognitive Impairment: MMSE score | ||||||
| Events, n (%) | 73 (49.32) | 69 (46.00) | 82 (55.03) | 92 (60.93) | — | 316 (52.84) |
| Model 1 | 1.00 | 0.94 (0.58‐1.50) | 1.20 (0.75‐1.92) | 1.62 (1.00‐2.61) | 0.02 | 1.17 (0.98‐1.41) |
| Model 2 | 1.00 | 0.98 (0.61‐1.58) | 1.24 (0.77‐2.02) | 1.79 (1.10‐2.93) | 0.009 | 1.21 (1.00‐1.46) |
| Model 3 | 1.00 | 0.98 (0.60‐1.59) | 1.26 (0.77‐2.07) | 1.80 (1.09‐2.97) | 0.01 | 1.23 (1.01‐1.48) |
| Model 4 | 1.00 | 0.97 (0.60‐1.59) | 1.25 (0.77‐2.07) | 1.79 (1.08‐2.96) | 0.01 | 1.23 (1.01‐1.48) |
| Cognitive Impairment: MoCA score | ||||||
| Events, n (%) | 85 (57.43) | 87 (58.00) | 99 (66.44) | 113 (74.83) | — | 384 (64.21) |
| Model 1 | 1.00 | 1.09 (0.68‐1.75) | 1.47 (0.90‐2.39) | 2.35 (1.41‐3.91) | <0.001 | 1.32 (1.07‐1.62) |
| Model 2 | 1.00 | 1.13 (0.69‐1.83) | 1.51 (0.91‐2.49) | 2.65 (1.56‐4.49) | <0.001 | 1.36 (1.10‐1.70) |
| Model 3 | 1.00 | 1.08 (0.66‐1.77) | 1.50 (0.90‐2.49) | 2.55 (1.49‐4.35) | <0.001 | 1.36 (1.09‐1.70) |
| Model 4 | 1.00 | 1.08 (0.66‐1.77) | 1.50 (0.90‐2.50) | 2.55 (1.49‐4.36) | <0.001 | 1.36 (1.09‐1.70) |
Model 1, adjusted for age, sex and education level.
Model 2, adjusted for model 1 and further adjusted for time from onset to randomization, systolic blood pressure, baseline National Institutes of Health Stroke Scale scores, body mass index, current smoking and alcohol drinking.
Model 3, adjusted for model 2 and further adjusted for medical history (hypertension, diabetes mellitus, hyperlipidemia and coronary heart disease), family history of stroke, use of antihypertensive medications and ischaemic stroke subtype.
Model 4 (sensitivity analysis), adjusted for model 3 and further adjusted for randomized treatment.
MMSE score of <27 or MoCA score of <25 indicates cognitive impairment.
Abbreviations: CI, confidence interval; MMSE, Mini‐Mental State Examination; MoCA, Montreal Cognitive Assessment; OR, odds ratio; TIMP‐1, tissue inhibitor of metalloproteinase‐1.