TABLE 4.

Joint effects of serum TIMP‐1 and matrix metalloproteinase‐9 (MMP‐9) on the risk of cognitive impairment after acute ischaemic stroke. The forest plot is misaligned with the Numbers (OR (95% CI))

Timp‐1 ≥184.2 ng/mL	MMP‐9 ≥462.6 ng/mL	Events No (%)	OR (95% CI)
Cognitive impairment: MMSE score
−	−	57(40.4)	Reference
+	−	39(50.7)	1.34(0.72‐2.48)
−	+	77(53.9)	1.95(1.17‐3.25)
+	+	123(62.4)	2.83(1.74‐4.60)
Cognitive impairment: MoCA score
−	−	73(51.8)	Reference
+	−	48(62.3)	1.41(0.75‐2.64)
−	+	89(62.2)	1.72(1.03‐2.89)
+	+	144(73.1)	2.99(1.81‐4.95)

Optimal cut points for TIMP‐1 and MMP‐9 were obtained from the ROC curves.

OR was adjusted for age, sex, education level, time from onset to randomization, systolic blood pressure, baseline National Institutes of Health Stroke Scale scores, body mass index, current smoking, alcohol drinking, medical history (hypertension, diabetes mellitus, hyperlipidemia and coronary heart disease), family history of stroke, use of antihypertensive medications and ischaemic stroke subtype.

Abbreviations: CI, confidence interval; OR, odds ratio.