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. 2020 May 29;24(13):7417–7426. doi: 10.1111/jcmm.15357

Figure 4.

Figure 4

ATR partially decreased the incidences of T2D in db/db mice. A, Serum insulin level of db/db mice was notably higher than other mice. B, Results of blood glucose tested after injection of 2 g/kg bodyweight during 2 h in glucose tolerance test. The increasing of blood glucose level in db/db mice was relieved by ATR administration. C, Malate concentration detected by LC‐MS. Malate concentration was down‐regulated in T2D mice and got retrieved to baseline level with ATR treatment. D, The protein expression level of ME1, ME2 and MDH1 in C57BL/6J mice, db/db mice and db/db mice treated with ATR. Relative protein expression levels of ME1, ME2 and MDH1 were significantly down‐regulated in db/db mice compared with the control groups, which was partially rescued to normal expression level with ATR treatment. Data = mean ±SD, n = 5 in each group, *P < .05, **P < .01, ***P < .001, compared with NC (C57BL/6J) group. # P < .05, ## P < .01, compared with db/db group