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A schematic model that summarizes that SIRT2 regulation of Hsp90‐GR signalling. In resting state, Hsp90 and GR form a complex in the cytoplasm. The binding of glucocorticoid to GR triggers release of GR from the complex. SIRT2 facilitates this process by deacetylation Hsp90. Upon release, GR forms a homodimer and translocates into the nucleus, where GR preferentially binds to the GRE in the promoter region of inflammatory cytokines and represses the transcriptional activation
