FIGURE 3.

Magnesium isoglycyrrhizinate (MGIG) improves energy metabolism via regulating the uptake of glutamate into tricarboxylic acid (TCA) cycle. Livers of each group were homogenized and mixed with 80% methanol solution containing 5‐¹³C‐glutamine for the following metabonomic analysis. The PLS‐DA plot of control, HFD model and MGIG groups for liver data (A). The sPLS‐DA 3D plot of control, HFD model and MGIG groups for liver data (B). Heatmaps exhibiting metabolites in livers of MGIG mice and HFD mice (C). The metabolites associated with glutamate and TCA cycle metabolic pathways in liver tissues after MGIG treatment (D). The data were presented as means ± SDs. Compared with Control group: ^# P < .05, ^## P < .01, ^### P < .001. Compared with Model group: *P < .05, **P < .01, ***P < .001 (Control: n = 8, HFD: n = 6; MGIG: n = 8)