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. 2020 May 15;24(13):7201–7213. doi: 10.1111/jcmm.15230

FIGURE 5.

FIGURE 5

Inhibition in Toll‐like receptor 4 binding pathway was associated with the protective effect of magnesium isoglycyrrhizinate (MGIG) intervention. Transcriptome profiling was conducted to further find the differential gene between MGIG mice and high‐fat diet (HFD) mice. Heatmap exhibiting the reversion of MGIG treatment in gene expression (A). The left column represents the differential genes when MGIG vs HFD model group, and the right column represents the differential genes when HFD model vs control group. The clustering of significant differential genes between MGIG group and HFD model group to find the pathways these genes involved in (B). The gene expressions of Toll‐like receptors (TLRs) isoforms were evaluated (C). The expressions of TLR4‐related genes were assessed (D). The data were presented as means ± SDs. Compared with Control group: # P < .05, ## P < .01, ### P < .001. Compared with Model group: *P < .05, **P < .01, ***P < .001 (n = 6)