Table 3.
Multivariable Cox regression analysis of clinical outcome (overall survival) in triple-negative breast cancer (TNBC) patients with respect to clinical parameters and the tumor biological factor KLK7
| Clinical parameters | OS 180 | ||
|---|---|---|---|
|
| |||
| Noa | HR (95% CI)b | p | |
| Age (years) | 0.078 | ||
| ≤ 50 | 47 | 1 | |
| > 50 | 79 | 1.70 (0.94-3.05) | |
| Tumor size | 0.942 | ||
| pT0+pT1 | 40 | 1 | |
| pT2+pT3+pT4 | 86 | 1.02 (0.56-1.87) | |
| Nodal status | 0.010 | ||
| pN0 | 71 | 1 | |
| pN1+pN2+pN3+ | 55 | 2.01 (1.18-3.43) | |
| Nuclear grade | 0.371 | ||
| G2 | 10 | 1 | |
| G3 | 116 | 1.60 (0.57-4.45) | |
| KLK7 IRSc | 0.040 | ||
| low | 92 | 1 | |
| high | 34 | 0.47 (0.23-0.97) | |
The biological marker KLK7 was added to a base model of the clinical parameters: age, tumor size, nodal status and nuclear grade. Significant p-values (P < 0.05) are indicated in bold.
a
Number of patients;
b
HR: hazard ratio (CI: confidence interval) of multivariable Cox regression analysis;
c
Dichotomized into low and high levels by the 75th percentile.