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. 2020 Jul 6;20:628. doi: 10.1186/s12885-020-07121-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Oncolysis with GLV-1 h68. SRB viability assays employing oncolytic vaccinia virus vector GLV-1 h68 on the NET/NEC cell line panel of six different tumor cell lines originating from different neuroendocrine neoplasms. Lung NET cell lines are shown in the upper panel (a, b), pancreatic NET cell lines in the middle (c, d), and intestinal NEC cell lines in the lower panel (e, f). Analysis was performed at 96 hpi. H727, BON-1 and HROC-57 cells were found to be highly permissive; UMC-11, QGP-1, and NEC-DUE1 cells were classified as permissive. BON-1 cells exhibited a quite strong response, requiring only MOI 0.01 to reach the threshold of 60% remaining tumor cells. Four independent experiments (six for UMC-11 cells) were carried out in quadruplicates; bars show mean and SD. The lowest MOI being significantly superior to mock treatment is indicated with * p < 0.01 or ** p < 0.001. Higher MOIs of the same cell line were also found to be significantly superior to mock treatment