Table 3.
Independent predictors of major adverse outcomes by multivariable Cox regression analysis in SCAD+AF group and ACS + AF group
| SCAD + AF | ACS + AF | ||||
|---|---|---|---|---|---|
| OR (95% CI) | P-value | OR (95% CI) | P-value | ||
| Ischemic stroke | Age ≥ 65 | 1.03 (1.01–1.06) | 0.007* | 1.44 (1.06–1.98) | 0.006* |
| Female | 1.35 (0.85–1.99) | 0.179 | 1.21 (0.93–1.60) | 0.117 | |
| Hypertension | 1.33 (1.04–1.72) | 0.014* | 1.50 (1.22–1.83) | 0.020* | |
| Heart failure | 0.99 (0.94–1.03) | 0.225 | 1.26 (0.89–1.78) | 0.193 | |
| Diabetes mellitus | 0.62 (0.27–1.46) | 0.214 | 0.92 (0.36–2.27) | 0.890 | |
| Previous stroke | 1.39 (1.12–2.17) | 0.009* | 1.25 (1.04–1.56) | 0.031* | |
| Previous bleeding | 1.68 (0.77–3.68) | 0.180 | 1.16 (0.57–2.42) | 0.713 | |
| Coronary stent | 0.81 (0.31–2.26) | 0.700 | 0.78 (0.37–1.53) | 0.440 | |
| OAC | 0.33 (0.25–0.46) | 0.016* | 0.54 (0.30–0.93) | 0.005* | |
| APT | 0.72 (0.42–1.10) | 0.113 | 0.88 (0.44–1.65) | 0.637 | |
| Bleeding | Age ≥ 65 | 1.29 (0.51–3.35) | 0.587 | 1.85 (1.28–2.66) | 0.020* |
| Female | 1.30 (0.57–2.93) | 0.508 | 0.90 (0.76–1.04) | 0.162 | |
| Hypertension | 1.10 (0.74–1.63) | 0.482 | 1.14 (0.95–1.33) | 0.148 | |
| Heart failure | 1.04 (0.75–1.45) | 0.912 | 0.67 (0.39–1.13) | 0.134 | |
| Diabetes mellitus | 0.95 (0.77–1.16) | 0.872 | 1.05 (0.87–1.23) | 0.960 | |
| Previous stroke | 1.17 (0.42–3.27) | 0.353 | 1.55 (0.70–3.45) | 0.172 | |
| Previous bleeding | 1.85 (1.12–3.07) | 0.001* | 1.78 (1.33–2.39) | 0.006* | |
| Coronary stent | 0.67 (0.41–1.11) | 0.621 | 1.34 (0.67–2.70) | 0.316 | |
| OAC | 1.17 (0.56–2.25) | 0.658 | 2.28 (0.58–3.91) | 0.243 | |
| APT | 1.32 (0.86–2.01) | 0.137 | 2.18 (0.71–6.73) | 0.171 | |
| MI | Age ≥ 65 | 1.65 (0.73–3.74) | 0.240 | 1.16 (0.56–2.13) | 0.723 |
| Female | 1.55 (0.83–2.91) | 0.133 | 0.93 (0.59–1.46) | 0.738 | |
| Hypertension | 1.34 (0.82–2.17) | 0.224 | 2.29 (0.71–7.40) | 0.166 | |
| Heart failure | 0.79 (0.40–1.62) | 0.557 | 0.99 (0.91–2.08) | 0.787 | |
| Diabetes mellitus | 1.26 (0.60–3.31) | 0.453 | 2.23 (1.75–2.83) | 0.001* | |
| Previous stroke | 1.42 (0.82–2.60) | 0.178 | 1.71 (0.69–4.27) | 0.248 | |
| Previous bleeding | 1.28 (0.70–2.64) | 0.430 | 1.51 (0.96–2.37) | 0.308 | |
| Coronary stent | 1.03 (0.89–1.17) | 0.713 | 0.95 (0.81–1.10) | 0.558 | |
| OAC | 0.90 (0.57–1.38) | 0.628 | 1.30 (0.65–2.58) | 0.639 | |
| APT | 0.71 (0.58–0.86) | 0.004* | 0.66 (0.56–0.79) | < 0.001* | |
| All-cause death | Age ≥ 65 | 1.67 (1.37–2.02) | 0.005* | 1.47 (1.21–1.79) | 0.001* |
| Female | 0.85 (0.57–1.28) | 0.470 | 0.93 (0.66–1.37) | 0.750 | |
| Hypertension | 1.01 (0.96–1.04) | 0.615 | 1.12 (0.93–1.31) | 0.087 | |
| Heart failure | 2.81 (1.82–4.34) | 0.028* | 3.02 (1.61–5.68) | 0.003* | |
| Diabetes mellitus | 0.84 (0.52–1.19) | 0.390 | 0.96 (0.67–1.38) | 0.839 | |
| Previous stroke | 1.11 (0.87–1.38) | 0.380 | 1.40 (0.55–3.23) | 0.560 | |
| Previous bleeding | 2.07 (0.72–5.71) | 0.184 | 1.28 (0.85–1.91) | 0.215 | |
| Coronary stent | 0.76 (0.54–1.09) | 0.119 | 0.70 (0.42–1.17) | 0.148 | |
| OAC | 0.32 (0.18–0.57) | < 0.001* | 0.47 (0.28–0.77) | 0.009* | |
| APT | 0.71 (0.54–0.95) | 0.015* | 0.57 (0.42–0.75) | < 0.001* | |
*Statically significant at p < 0.05. Abbreviations: OR odds ratio, CI confidence interval, SCAD stable coronary artery disease, ACS acute coronary syndrome, AF atrial fibrillation, MI myocardial infarction, OAC oral anticoagulant, APT antiplatelet therapy