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. 2020 May 7;22(2):733–738. doi: 10.3892/mmr.2020.11139

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Copyright: © Sun et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Syntenin silencing activates the p38 MAPK signaling pathway. (A) Phosphorylation of p38 MAPK was significantly increased after transfection of syntenin-siRNA in melanocytes. (B) Melanin content and (C) tyrosinase activity were significantly increased after transfection of syntenin-siRNA, but this effect was abolished with co-treatment with p38 MAPK inhibitor SB203580. *P<0.05 vs. Blank group. NC, Negative control; p, phosphorylated; p38, p38 mitogen-activated protein kinase; SB, SB203580; siRNA, small interfering RNA; syn, syntenin.