Table 5.

The linkage of QRDRs mutations with antimicrobial susceptibility profile

Isolate No.	Serotype	MAR	MIC (μg/ml)		Mutations-changes in codons
			CIP	LEV	gyrA	gyrB	parC	parE
1	Typhimurium	0.33	<=0.25	<=0.12	–	–	–	–
2	Typhimurium	0.46	0.5	0.5	–	–	–	–
3	Typhimurium	0.63	1	2	–	CTT → CTC, TCC → TCTc	GTT → GTC, CAC → CAT, CAT→CAC, GCG → GCA, TCC → TCTd	ACT→ACGe, CAC → CATf
4	Bovismorbificans	0.38	1	0.5	GAC → GGCa	CTT → CTC, TCC → TCT	–	ACT, CAC → CAT
5	Typhimurium	0.50	1	0.5	GAC → GGC	CTT → CTC, TCC → TCT	–	ACT, CAC → CAT
6	Enteritidis	0.33	0.5	2	–	CTT → CTC, TCC → TCT	–	ACT, CAC → CAT
7	London	0.33	1	1	–	CTT → CTC, TCC → TCT	GTT → GTC, CAC → CAT, CAT→CAC, GCG → GCA, TCC → TCT	ACT, CAC → CAT
8	Typhimurium	0.33	2	1	GAC → AACb	–	–	–
9	Agona	0.63	1	1	–	CTT → CTC, TCC → TCT	GTT → GTC, CAC → CAT, CAT→CAC, GCG → GCA, TCC → TCT	ACT→ACG, CAC → CAT
10	London	0.42	1	1	GAC → AAC	CTT → CTC, TCC → TCT	GTT → GTC, CAC → CAT, CAT→CAC, GCG → GCA, TCC → TCT	–
11	Litchfield	0.25	1	1	GAC → AAC	CTT → CTC, TCC → TCT	–	–
12	4, 5, 12, i: -	0.21	1	1	–	–	–	–
13	Enteritidis	0.08	1	1	GAC → AAC	CTT → CTC, TCC → TCT	–	ACT, CAC → CAT
14	London	0.13	2	0.5	GAC → AAC	CTT → CTC, TCC → TCT	GTT → GTC, CAC → CAT, CAT→CAC, GCG → GCA, TCC → TCT	ACT→ACG, CAC → CAT
15	4, 5, 12, i: -	0.50	2	2	GAC → AAC	–	–	–
16	untypable	0.42	2	4	GAC → AAC	–	–	–
17	4, 5, 12, i: -	0.42	> = 4	4	GAC → AAC	–	–	–
18	Typhimurium	0.42	2	2	GAC → AAC	–	–	–
19	Typhimurium	0.63	> = 4	> = 8	GAC → AAC	–	–	–
20	Typhimurium	0.46	2	4	GAC → AAC	–	–	–
21	Typhimurium	0.58	> = 4	4	GAC → AAC	–	–	–

Base pair changes in bold type.

MIC minimum inhibitory concentration, CIP ciprofloxacin, LEV levofloxacin.

- No mutation

^aAmino acid alteration is Asp-87 → Gly.

^bAmino acid alteration is Asp-87 → Asn.

^cAmino acid alterations are Leu-462 → Leu, Ser-464 → Ser.

^dAmino acid alterations are Val-67 → Val, His-75 → His, His-77 → His, Ala-117 → Ala, Ser-123 → Ser.

^eAmino acid alteration is Thr-500 → Thr.

^fAmino acid alteration is His-509 → His.