Table 3.

Subgroup analyses based on histology type

Subgroup	No. of studies	No. of patients	HR (95% CI)	P value	Heterogeneity
Subgroup	No. of studies	No. of patients	HR (95% CI)	P value	I² (%)	Ph
OS in nonmetastatic RCC
Overall	8	4113	1.78 (1.24–2.56)	< 0.001	85	0.002
Clear cell RCC	4	2506	1.75 (1.03–2.99)	0.04	69	0.04
Others	4	1607	2.15 (1.61–2.87)	< 0.001	6	0.36
OS in metastatic RCC
Overall	11	1420	2.04 (1.58–2.64)	< 0.001	72	< 0.001
Clear cell carcinoma	3	309	2.24 (1.55–3.25)	< 0.001	0	0.92
Others	8	1111	1.99 (1.47–2.68)	< 0.001	77	< 0.001
DFS in nonmetastatic RCC
Overall	8	3602	1.45 (1.19–1.78)	< 0.001	81	< 0.001
Clear cell carcinoma	3	1450	1.75 (1.27–2.43)	< 0.001	0	0.46
Others	5	1325	1.58 (1.16–2.15)	0.004	71	0.009
PFS in metastatic RCC
Overall	9	891	2.99 (2.82–3.18)	< 0.001	18	0.28
Clear cell carcinoma	4	382	2.40 (1.82–3.18)	< 0.001	0	0.64
Others	5	509	3.02 (2.84–3.22)	< 0.001	28	0.24
CSS in nonmetastatic RCC
Overall	4	2314	2.31 (1.61–3.33)	< 0.001	14	0.32
Clear cell carcinoma	3	1679	2.77 (1.78–4.32)	< 0.001	0	0.47
Others	1	635	–	–	–	–