Table 2.
GO analysis of predicted target genes of five validated C19MC miRNAs
| Subcategory | GO name | numbers | P-value | Targeted mRNA |
|---|---|---|---|---|
| positive regulation of phosphatidylinositol 3-kinase activity | GO:0043552 | 15 | 0.0005 | CCR7, FGR, SRC, TNFAIP8L3, ATG14, ERBB4, FGFR3, FLT1, IRS1, PDGFB, PTK2B, PTK2, TGFB1, VAV2, VAV3 |
| post-embryonic development | GO:0009791 | 22 | 0.017 | ALX4, MORC3, PLAGL2, PRDM1, SMAD2, SOX6, TAL2, TIPARP, ACVR2B, ALDH5A1, AGO2, CHST11, EMX1, GABRG2, HEG1, ITPR1, IMPAD1, KMT2A, PYGO1, SZT2, SELENOP, SOD2 |
| memory | GO:0007613 | 19 | 0.023 | HTR2A, CHRFAM7A, NTAN1, SHANK2, CNR1, DRD1, EIF4EBP2, FEN1, HRH1, HRH2, ITGA3, KALRN, PAK5, PLA2G6, PLCB1, KCNK10, KCNK4, PPP3CB, SLC6A4, |
| response to hydrogen peroxide | GO:0042542 | 16 | 0.032 | BAK1, SRC, CASP3, DUSP1, GLRX2, GPX1, HP, HMOX1, MB, NR4A3, PPP1R15B, PTK2B, STK25, STAT1, SOD2, SDC |
| T cell differentiation | GO:0030217 | 11 | 0.033 | CD3D, SOX4, SP3, CHD7, IL7R, NHEJ1, PREX1, PIK3CD, PPP3CB, PTPN2, PTPN22 |
| glucose homeostasis | GO:0042593 | 27 | 0.034 | ALMS1, CSMD1, HECTD4, HNF1A, SOX4, VGF, ADIPOR2, CNR1, CAV3, CRY1, CRY2, DHPS, FBN1, HNF4A, HIF1A, INPP5K, IRS1, INSR, NEUROD1, PRCP, PRKAA1, PRKAA2, PTPN2, RBP4, SLC2A4, SLC8B1, TCF7L2 |
| MAPK cascade | GO:0000165 | 60 | 0.038 | BRAP, CCL5, FYN, JAK1, NDST1, RASGRP3, RASGRP4, RASA1, RASA2, RAF1, RASGEF1A, SHC3, ACTN2, CAMK2B, CAMK2D, CAMKK2, CALM3, CSF2RA, CSF2RB, DOK4, DOK5, DUSP5, DUSP7, EGFR, EREG, ERBB3, ERBB4, FGF19, FGF7, FGFR3, GRB2, ITPKB, IRS1, IL17RD, IL2RB, IL31RA, KLB, LRRK2, MAPK4, MAPK8IP2, MAPKAPK3, MEF2D, NRG1, NF1, PDGFB, PSMD1, PSMD5, PSME3, PSME4, PSMA2, PSMB4, PTK2B, PTK2, RET, SPTA1, SPTB, SPTBN1, SPRED1, TGFB1, MYC |
| nervous system development | GO:0007399 | 67 | 0.038 | MTR, DGCR14, GPSM1, RFNG, RBM45, ARHGEF7, SMARCC1, WNT8B, ZIC5, ATXN10, ATXN3, CHRM2, CHRM3, CHRDL1, CPLX2, CRIM1, DPYSL5, DOK4, DOK5, DYRK1A, EDNRB, ERBB4, FEZ1, FEZ2, FGF19, FUT10, FKTN, GBX2, GMFB, GRIK1, GPM6B, GAS7, HDAC4, IGSF9B, INSC, KALRN, LSAMP, MPPED2, MARK4, MAP1B, MBNL1, MEF2D, NRG1, NLGN1, NAV2, NR2E1, PRPS1, PCSK2, PPP2R5D, PCDHA10, PCDHA11, PCDHA2, PCDHA4, PCDHA5, PCDHA8, SEMA6A, SRRM4, SHOX2, SIGMAR1, SCN8A, TSHR, TMEM41B, TPP1, TMOD2, ZEB2, |
Gene names and their numbers of predicted target mRNAs are listed in each GO subcategory. P value of < 0.05 was considered significant