Table 2.
Concurrent diagnoses in patients with migraine in the German Company Sickness Fund Database 2008 to 2016
| ICD-10-GM code | Diagnosis | Men (n = 53,653) (%) |
Women (n = 189,818) (%) |
Overall (n = 243,471) (%) |
|---|---|---|---|---|
| Most common concurrent diagnoses | ||||
| M54 | Dorsalgia | 78.2 | 82.7 | 81.7 |
| J06 | Acute upper respiratory infections of multiple and unspecified sites | 67.0 | 66.1 | 66.3 |
| H52 | Disorders of refraction and accommodation | 55.6 | 63.8 | 61.9 |
| R10 | Abdominal and pelvic pain | 40.0 | 64.4 | 59.0 |
| F45 | Somatoform disorders | 38.1 | 55.4 | 51.6 |
| M99 | Biomechanical lesions, not elsewhere classified | 45.2 | 52.0 | 50.5 |
| I10 | Essential (primary) hypertension | 43.1 | 38.5 | 39.6 |
| N89 | Other non-inflammatory disorders of vagina | – | 65.6 | –a |
| Concurrent diagnoses of special interest occurring in > 10% of patients in men, women or overall | ||||
| F32–F33 | Depressive episode – recurrent depressive disorderb | 33.4 | 45.5 | 42.9 |
| F40–F41 | Phobic and other anxiety disordersc | 17.1 | 27.5 | 25.2 |
| J45 | Asthmad | 14.7 | 17.0 | 16.5 |
| K70–K77 | Diseases of livere | 15.7 | 12.2 | 13.0 |
| I95 | Hypotensiond,f | 6.9 | 14.3 | 12.7 |
| I49 | Other cardiac arrhythmiasd | 10.8 | 11.8 | 11.6 |
| E10–E14 | Diabetes mellitusd | 12.4 | 10.0 | 10.6 |
| N40 | Hyperplasia of prostateg | 19.7 | – | –a |
aBecause this diagnosis could only affect one gender, to provide an overall percentage would be misleading
bContraindication or special warning and precaution for use for beta-blockers, flunarizine and topiramate
cContraindication or special warning and precaution for use for topiramate
dContraindication or special warning and precaution for use for beta-blockers
eContraindication or special warning and precaution for use for valproic acid
fSurrogate marker for orthostatic dysregulation
gContraindication or special warning and precaution for use for amitriptyline
Selections of contraindications were based on the guideline by the German Migraine and Headache Society and the German Society of Neurology [8]
ICD-10-GM International Classification of Diseases, 10th revision, German modification; − not applicable