Table 3.
Prescribed in- and off-label (Group 2) preventive medications for patients with migraine in the German Company Sickness Fund Database 2016
| Class Preventive medication |
Percentage of all prescriptions for preventive medications |
|---|---|
| Beta-blockers | 53.8 |
| Metoprolol | 29.6 |
| Bisoprolol | 21.0 |
| Propranolol | 3.2 |
| ACEis and ARAs | 22.4 |
| ARAs (‘sartans’) | 20.1 |
| Lisinopril | 2.3 |
| Antidepressants | 16.0 |
| Amitriptyline | 9.5 |
| Opipramol | 6.5 |
| Anticonvulsants | 5.7 |
| Topiramate | 4.2 |
| Valproic acid | 1.5 |
| Muscle relaxants | 0.8 |
| Onabotulinum toxin Aa | 0.8 |
| Calcium channel blockers | 0.8 |
| Flunarizine | 0.8 |
| Magnesium compounds | 0.5 |
Data shown are for prescribed Group 2 preventive medications (all preventive medications according to the German guideline for migraine [8])
aPrescriptions for the Allergan brand of onabotulinum toxin A only were included
ACEi angiotensin-converting enzyme inhibitor; ARA angiotensin II receptor antagonist