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. Author manuscript; available in PMC: 2020 Jul 7.
Published in final edited form as: Sci Transl Med. 2020 Jan 15;12(526):eaay1769. doi: 10.1126/scitranslmed.aay1769

Fig. 7. Patients with ET develop excessive cerebellar oscillations.

Fig. 7.

(A and B) Human cerebellar electroencephalogram (EEG) recorded in the different cerebellar regions in both patients and controls. (C and D) Representative time-frequency plots (C), and corresponding PSD diagrams and group analysis [(D) n = 10 patients and 10 age-matched controls; ***P < 0.001 by Mann-Whitney test]. (E to H) Source localization and bipolar comparison of cerebellar oscillations in patients with ET. EEG was recorded in awake patients under eyes-open condition to suppress occipital alpha rhythm. Location of EEG leads (E) and representative PSD diagrams (F) with color-coded EEG intensity at human tremor frequency (4 to 12 Hz). The highest intensity (red) is located in the cerebellar region. Direct comparison between cerebellar leads (Cb2-Cb1) and occipital leads (O2-O1) in a representative patient (G) and group analysis [(H) n = 5 patients; *P < 0.05 by Wilcoxon signed-rank test]. (I) Cerebellar oscillatory index (COI) and its correlation with tremor severity in patients in an extended cohort (n = 20 patients, r = 0.64, P = 0.002 by Pearson’s correlation coefficient). Error bars denote SEM.