Table 4.

Percentage of variants in functional classes of annotation

Annotation	All variants	p_fat % ≤ 10−8	p_prot % ≤ 10−8
Intergenic	65.85	51.45	50.07
Intron	26.54	35.12	35.84
Upstream_gene	3.49	5.91	5.89
Downstream_gene	3.04	4.24	4.83
Synonymous	0.36	0.99	0.91
Missense	0.32	0.54	0.54
3_prime_UTR	0.22	0.32	0.44
Splice_region	0.06	0.14	0.14
5_prime_UTR	0.05	0.12	0.11
Non_coding_transcript_exon	0.03	0.15	0.12
Other	0.02	0.01	0.02
Not annotated	0.02	1.01	1.09

p_fat % ≤ 10⁻⁸ and p_prot % ≤ 10⁻⁸ = variants with a p-value ≤ 10⁻⁸ in the meta-analysis for fat and protein percentage, respectively