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. 2020 Jun 2;22(2):1119–1128. doi: 10.3892/mmr.2020.11200

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Copyright: © Gao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Effect of cyclic stretch on the expression of molecules involved in the IHH signaling pathway in OLF cells. Cyclic stretch of OLF cells resulted in significant increases in the (A) mRNA and (B) protein expression levels of IHH. Cyclic stretch of OLF cells resulted in significant increases in the (C) mRNA and (D) protein expression levels of SMO at 6, 12 and 24 h. mRNA expression levels of (E) GLI1 and (F) GLI2 were significantly increased after cyclic stretch. (G) No significant effect was observed on the expression level of GLI3. *P<0.05, **P<0.01, ***P<0.001. Data are presented as the mean ± SD. N=3. OLF, ossification of ligamentum flavum; RUNX2, Runt-related transcription factor 2; ALP, alkaline phosphatase; OCN, osteocalcin; IHH, Indian hedgehog; SMO, Smoothened; GLI, GLI family zinc finger.