Table 3.

Risk of bias of the included studies.

Study	A	B	C	D	E	F	G	H	I	J	Total
Gui et al., 2012	√	√				√			√	√	5
Chen et al., 2014	√	√	√			√			√	√	6
Lu et al., 2015	√		√							√	3
Wang et al., 2015	√	√				√				√	4
Chen and Chen, 2016	√	√	√			√				√	5
Guo et al., 2016	√	√	√	√					√	√	6
Huang et al., 2016	√	√	√			√				√	5
Li and Zhang, 2016	√	√	√	√		√				√	6
Ran and Ma, 2016	√	√	√						√	√	5
Sun et al., 2016	√	√	√	√					√	√	6
Guo et al., 2017	√	√	√							√	4
Liu et al., 2017	√	√	√	√		√			√	√	7
Wang et al., 2017	√	√	√	√		√			√	√	7
Du et al., 2018	√		√			√			√	√	5
Han et al., 2018	√	√	√	√						√	5
He et al., 2018	√	√	√							√	4
Li et al., 2018		√	√	√		√			√	√	6
Lei et al., 2018a	√	√		√					√	√	5
Lei et al., 2018b	√	√	√			√			√	√	6
Fan et al., 2019	√	√		√		√			√	√	6
Ju et al., 2019	√	√	√	√		√	√		√	√	8
Liu et al., 2019	√	√	√	√						√	5
Ma et al., 2019	√	√	√	√		√			√	√	7
Song et al., 2020	√	√	√							√	4

Studies fulfilling the criteria of: A: peer reviewed publication; B: control of temperature; C: random allocation to treatment or control; D: blinded induction of model (group randomly after modeling or transgenic mice or knockout mice); E: blinded assessment of outcome; F: use of anesthetic without significant renal protective activity or nephrotoxicity; G: appropriate animal model (aged, hyperlipemia or hypertensive); H: sample size calculation; I: compliance with animal welfare regulations (including three or more of the following points: preoperative anesthesia, postoperative analgesia, nutrition, disinfection, environment temperature, environment humidity, circadian rhythm, and euthanasia); J: statement of potential conflict of interests.