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. 2020 May 18;22(2):633–642. doi: 10.3892/mmr.2020.11150

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Copyright: © Fan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Negative correlation between miR-205 and MDM4 expression in colon cancer tissue. Reverse transcription-quantitative PCR was performed to determine the mRNA levels of (A and B) miR-205 and (C and D) MDM4 in the colon cancer tissues, adjacent normal tissues and human colon cancer cell lines (HT29, HCT116, HCT8, LS174T and SW480). U6 and GAPDH were internal references. *P<0.05 and **P<0.01 vs. normal or HT29. (E) Western blot analysis was used to determine the protein expression of MDM4 in the colon cancer tissues and adjacent normal tissues. (F) Correlation between the miR-205 and MDM4 mRNA expression was quantified. miR, microRNA; MDM4, mouse double minute 4.