Table V.

Univariate and multivariate Cox regression analysis for overall survival.

	Univariate Cox regression			Multivariate Cox regression
Variables	P-value	HR	95% CI	P-value	HR	95% CI
Risk score (high/low)	0.003a	4.949	1.735–14.117	0.001a	3.393	1.597–7.210
Age (>60/≤60)	0.202	1.816	0.726–4.543
BMI	0.060
<25	Reference
≥25		0.245	0.073–0.818
Not reported		0.779	0.096–6.340
Race	0.423
Non-Asian	Reference
Asian		0.352	0.053–2.322
Not reported		1.915	0.115–31.769
Sex (Male/Female)	0.143	2.590	0.725–9.251
Hepatitis B or C	0.542
No	Reference
Yes		1.489	0.415–5.346
Cirrhosis	0.216
Non-cirrhosis	Reference
Cirrhosis		3.183	0.524–19.324
Not reported		0.572	0.178–1.843
Histologic grade	0.586
G1-2	Reference
G3-4		1.326	0.481–3.649
New tumor event	0.406
No	Reference
Yes		1.126	0.216–5.883
Not reported		16.771	0.260–1080.40
Pathologic stage	0.093
Stage I+II	Reference
Stage III+IV		2.857	0.935–8.730
Not reported		3.173	0.740–13.617
Cancer status	0.998
Tumor free	Reference
With tumor		1.052	0.196–5.635
Not reported		0.000	0.000
Family cancer history	0.031			0.126
No	Reference	Reference
Yes		0.667	0.234–1.899		0.868	0.419–1.799
Not reported		0.076	0.011–0.528		0.206	0.045–0.953
Residual tumor	0.611
R0	Reference
Non-R0		0.469	0.105–2.092
Not reported		0.000	0.000
Vascular invasion		0.006a		0.005a
Negative	Reference	Reference
Positive		3.019	0.798–11.416		2.146	0.903–5.104
Not reported		8.383	2.264–31.038		3.577	1.652–7.748

^aP<0.05. BMI, Body mass index; AFP, α fetoprotein; HR, Hazard ratio; CI, Confidence interval.