Table 12-2.
Major Sertoli cell secretory products
| Products | Functions and/or characteristics |
|---|---|
| Transport-Binding Proteins | |
| Androgen-binding protein (ABP) | Androgen transport |
| Transferrin | Iron transport |
| Ceruloplasmin | Copper transport |
| Sulfated glycoprotein-1 | Sphingolipid binding |
| Regulatory Proteins | |
| Inhibin | Endocrine-paracrine agent |
| Müllerian duct inhibitory agent | Development |
| Sulfated glycoprotein-2 | Sperm coating-immunosuppressant |
| Growth Factors | |
| TGF-α | Growth stimulation |
| TGF-β | Growth inhibition |
| IGF-1 | Maintain growth/differentiation |
| IL-1 | Growth regulation |
| Metabolites | |
| Lactate-pyruvate | Energy metabolites |
| Estrogens | Steroid hormone–endocrine–paracrine |
| Proteases/inhibitors | |
| Plasminogen activator | Plasminogen activation |
| Cyclic protein-2 | Cathepsin activity |
| α2-Macroglobulin | Protease inhibitor |
| Extracellular Matrix Components | |
| Laminin | |
| Collagens I and IV | |
| Proteoglycans | |
TGF, transforming growth factor; IGF-1, insulin-like growth factor; IL-1, interleukin.