Table 12-7.

Variants of Sertoli cell-only syndrome

Testis pattern	Variants of the Sertoli cell-only syndrome
	Immature Sertoli cells	Dysgenetic Sertoli cells	Adult Sertoli cells	Involuting Sertoli cells	Dedifferentiated Sertoli cells
Tubular diameter	Very decreased	Decreased	Decreased	Decreased	Decreased
Tubular lumen	Small or absent	Small or absent	Normal	Normal	Normal
Lamina propria thickness	Thin	Enlarged	Normal or enlarged	Normal or enlarged	Enlarged
Elastic fibers in lamina propria	Absent	Decreased	Normal	Normal	Normal
Sertoli cells
Number	Very increased	Increased	Normal or increase	Normal or increased	Increased
Distribution	Pseudostratified	Pseudostratified	Columnar	Columnar	Columnar or pseudostratified
Nuclear shape	Ovoid	Round or ovoid	Triangular	Lobated	Round
Nuclear outline	Regular	Regular	Few indented	Very indented	Regular
Chromatin	Dark	Pale with granules	Pale	Pale	Pale
Nucleolus	Small, peripheral	Developed, central	Developed, central	Developed, central	Small, central or peripheral
Vacuoles	Absent	Present	Present	Abundant	Abundant
Lipids	Absent	Absent	Decreased	Abundant	Abundant
Vimentin filaments	Basal	Basal	Basal and perinuclear	Basal and perinuclear	Basal
Antimüllerian hormone	Present	Present	Absent	Absent	Absent
Interstitium	Scanty	Increased	Normal	Normal/fibrosis	Fibrosis
Leydig cells	Absent	Pleomorphic, vacuolated, increased or decreased	Normal	Decreased, many lipofuscin granules	Decreased, many lipofuscin granules
Clinical symptoms	Hypogonadotropic hypogonadism	Infertility	Infertility, orchitis	Infertility, hypergonadotropic hypogonadism, chemo- or radiotherapy	Treatment with estrogens, antiandrogens or cisplatinum, chronic hepatopathy