Table 3.
The model parameters that gave the best fit to the MFI data.
| Label on mAb | K1 | K2 | [To], nmol/L | Bkg | G, MFI/nmol | Label gain MFI/mAb | Total CD4 on cell | Binding | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | FITC-Co1 | 3.71*10−2 | 8.39*10+3 | 0.371 | 0 | 20038 | 0.067 | 111700 | monovalent |
| 2 | Std. Dev. | 3.6*10−3 | 3.19*10+4 | 0.004 | 43 | 180 | 0.001 | 1180 | |
| 3 | FITC-Co2 | 7.60*10−3 | 5.52*10+4 | 0.386 | 677 | 22590 | 0.074 | 116300 | monovalent |
| 4 | Std. Dev. | 6.1*10−3 | 4.5*10+5 | 0.014 | 180 | 670 | 0.003 | 4200 | |
| 5 | APC-Co1 | 7.00*10+5 | 7.21*10−10 | 0.463 | 3760 | 19960 | 0.066 | 139400 | divalent |
| 6 | Std. Dev. | 4.94*10+5 | 1.06*10−9 | 0.011 | 65 | 390 | 0.002 | 3240 | |
| 7 | APC-Co2 | 5.99*10+6 | 3.69*10−10 | 0.527 | 555 | 42200 | 0.142 | 159000 | divalent |
| 8 | Std. Dev. | 4.09*10+6 | 6.4*10−10 | 0.022 | 219 | 1500 | 0.007 | 6800 |