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. 2020 Jun 16;22(2):1373–1381. doi: 10.3892/mmr.2020.11242

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Copyright: © Huang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Knockdown of RP105 increases the expression levels of TLR2 and TLR4 in MIRI. Protein expression levels of serum (A) TLR2 and (B) TLR4 in each group. (C) Western blotting for the expression levels of TLR2 and TLR4 in each group. The interactions of MD2 with TLR2 and TLR4 following overexpression or knockdown of RP105 were investigated. Expression level of (D) TNF-α and (E) IL-6 in each group. (F) Western blotting bands of TNF-α and IL-6. *P<0.05, **P<0.01. Ad, adenovirus; RP105, radioprotective 105 kDa protein; siRNA, small interfering RNA; EGFP, enhanced green fluorescent protein; sham, control sham group; I/R, ischemic and reperfusion; Ad-R, Ad-RP105 group; Ad-R-siRNA, Ad-RP105-siRNA group; Ad-G-siRNA, Ad-EGFP-siRNA group; TLR2/4, Toll-like receptor 2/4; TNF-α, tumor necrosis factor; IL-6, interleukin 6; MD2, myeloid differentiation protein 2; IP, immunoprecipitation.