Table II.
Candidate genes and their possible association to glaucoma pathogenesis.
| Gene | Location | Possible glaucoma mechanism/effect |
|---|---|---|
| MYOC/TIGR | 1q24 | TM, outflowa |
| CYP1B1 | 2p22.2 | Anterior segment dysgenesis |
| OPTN | 10p13 | Autophagy, apoptosis |
| TBK1 | 12q14 | Autophagy, inflammatory response |
| WDR36 | 5q22 | TM via apoptosis |
| NTF4 | 19q13.33 | Impaired neuronal survival |
| ASB10 | 7q36 | Outflow |
| ATOH7 | 10q21 | DA, VCDR, CA, POAG risk |
| CAV1/CAV2 | 7q31 | IOP changes, outflow |
| CDKN2B-AS1 | 9p21 | VCDR |
| SIX6 | 14q23 | VCDR, myopia, reduced RNFL thickness |
| TMCO1 | 1q24.1 | IOP changes, increased POAG risk |
| ABCA1 | 9q31 | Inflammatory response, neurodegeneration |
| AFAP1 | 4p16.1 | Unknown |
| ARHGEF12 | 11q23.3 | IOP changes, outflow |
| TXNRD2 | 22q11 | Oxidative stress |
| FOXC1 | 6p25.3 | Anterior segment dysgenesis |
| ATXN2 | 12q24.12 | Neurodegeneration |
| GAS7 | 17p13 | CA, IOP changes |
| GALC | 14q31.3 | Increased POAG risk |
a
Outflow, aqueous humor outflow. TM, trabecular meshwork; DA, disc area; VCDR, vertical cup-to-disc ratio; CA, cup area; POAG, primary open angle glaucoma; RNFL, retinal nerve fiber layer.