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. 2020 Jun 10;22(2):1518–1526. doi: 10.3892/mmr.2020.11218

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Copyright: © Suzuki et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — JQ1-induced downregulation of myofibroblast markers. (A) Changes in expression of α-SMA and ED-A-FN in NHLF and 46G-F cells observed by western blotting. The signal of β-actin for each lane was determined as an internal control. (B) The signal of each sample was determined using a densitometer and normalized to each internal control. Signal values are presented as fold changes from the control value of NHLF and as means ± SEM (n=3). *P<0.05 (ANOVA followed by Tukey's test). (C) Quantitative PCR analysis of ACTA2 and FN1 expression in 46G-F cells treated with PBS (NC) or JQ1. Quantitative data are presented as fold-changes from the control value and as means ± SEM (n=3). *P<0.05 (unpaired Student's t-test). ACTA2, actin α 2, smooth muscle; FN1, fibronectin 1; NC, normal control; NHLF, normal human lung fibroblasts; n.s., not significant.