Table II.
The effect of caudatin on biochemical markers of hepatic injury in DEN rats.
| Treatment | ALT, U/ml | AST, U/ml | TBIL, mg/dl | MDA, mol/g tissue |
|---|---|---|---|---|
| Control | 10.85±1.01 | 14.75±0.71 | 0.27±0.08 | 336.70±23.98 |
| DEN | 30.65±2.02a | 36.04±2.48a | 1.02±0.18a | 528.18±58.42a |
| Caudatin 25 mg/kg | 27.29±1.60b | 28.35±1.18b | 0.83±0.11 | 436.79±22.97b |
| Caudatin 50 mg/kg | 18.61±0.85b | 23.10±1.18b | 0.77±0.19b | 370.19±32.57b |
Each value is expressed as mean ± standard deviation (n=6/group).
a
P<0.01 vs. control
b
P<0.05 vs. DEN. DEN, diethylnitrosamine; ALT, alanine transaminase; AST, aspartate aminotransferase; TBIL, total bilirubin; MDA, malondialdehyde.