Fig. 4.

A combined clinical and genetic risk model for stratification in ATRT

Kaplan–Meier analyses (A). Patients with the risk factors age < or ≥1 year and features of the ATRT-TYR or non-TYR DNA-methylation subgroups were analyzed for their 5-year OS. Three risk strata were delineated: high risk (<1 y + non-TYR; 5-y OS 0%), intermediate risk (<1 y + TYR or ≥1 y + non-TYR; 5-y OS 32.5 ± 8.7%), and standard risk (≥1 y + ATRT-TYR; 5-y OS 71.5 ± 12.2). Potential risk model for the stratification of ATRT. (B) Age at diagnosis (<1 y vs ≥1 y) and DNA methylation subgroup (non-TYR vs TYR) may predict the potential risk of patients affected by ATRT independently of any other clinical or known genetic factor.