Table 3.

Significant prognostic factors in ATRT

		Univariate Analysis	Multivariate Analysis
		P	RR (95% CI)	P
Independent	Age <1 y vs ≥1 y	<0.0001	4.0 (2.2−7.4)	<0.0001
	TYR vs non-TYR	0.04	0.4 (0.2−0.7)	0.004
Not independent	Synchronous tumor yes vs no	<0.0001
	Metastases yes vs no	<0.0001
	Radiotherapy yes vs no*	0.006
	CR yes vs no	<0.0001
	GLM yes vs no	0.0002

Note. Age, localization, synchronous tumors, M+ status, GTR, conventional chemotherapy according to EU-RHAB, radiotherapy, HDCT, maintenance therapy, CR, progress or early relapse, GLM, and genetic subgroups were analyzed. Factors with significance on a univariate and multivariate level are listed (see also Supplementary Table 5).

Abbreviations: RR, relative risk; n.a., not applicable.

*Only patients irradiated with a curative intent (n = 93) were analyzed.