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. 2020 Jun 30;11:669. doi: 10.3389/fphys.2020.00669

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Copyright © 2020 Shi, Xiao, Liu, Chen, Xu, Fan and Yin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Notch3 promotes the apoptosis of rat cardiac fibroblasts (CFs). (A,B) Representative western blot and quantitative data of cleaved caspase3, total caspase3, and Bcl2 after notch3 overexpression or knockdown (n = 3). (C,D) The CF apoptotic rate after notch3 overexpression or knockdown, detected by flow cytometry. Q1-UR and Q1-LR were used to analyze the change of apoptotic rate in different experimental groups (n = 3). Values represent the mean ± SD. *P < 0.05, **P < 0.01. C-caspase3, cleaved caspase3; T-caspase3, total caspase3.