. Author manuscript; available in PMC: 2020 Jul 7.

Published in final edited form as: Prostate. 2011 Feb 9;71(13):1382–1389. doi: 10.1002/pros.21354

Table I.

Information about 14 genotyped SNPs in five arachidonic acid metabolism pathway genes

Genes	SNP ID	SNP region	Base change	P, HWE^a	Basis of selection
Genes	SNP ID	SNP region	Base change	P, HWE^a	Details	Reference^b	Epidemiologic Associations	Reference
Prostaglandin Synthesis Subpathway
PTGS2/ COX2	rs2745557	Intronic	G>A	0.40		(15)	Prostate cancer	(16)
PTGES2	rs884115	Intronic	C>T	0.72	Haplotype tagging SNP	(36)
	rs10987883	Intronic	A>G	0.85	Haplotype tagging SNP	(36)
	rs13283456	Intronic	C>T	0.25	Missense; Arg298His		Body mass index; Type 2 diabetes	(36,37)
	rs4837240	3’ UTR	G>A	0.18	Haplotype tagging SNP	(36)
Leukotriene Synthesis Subpathway
ALOX5	rs2029253	Intronic	A>G	<.001			Acute coronary syndrome	(38)
	rs12762303	Promoter	T>C	0.41			Coronary artery disease	(39)
	rs2228065	Exon 6	G>T	1.0	Missense; Glu254Lys	(40)	Tuberculosis	(41)
	rs6593482	VNTR	G>T	<.001
ALOX5AP	rs12721458	Intronic	C>G	0.84
	rs4076128	5’UTR	A>G	<.001			Breast cancer	(10)
	rs4073259	5’UTR	G>A	0.13			Myocardial infarction	(42)
LTA4H	rs2660845	5’UTR	A>G	0.17			Asthma	(43)
	rs1978331	Intronic	T>C	0.65	Higher level of LB4^c associated with T allele	(33,42)	Asthma; leprosy; tuberculosis	(30,33)

P-values from Chi-squared test for Hardy-Weinberg equilibrium in controls. SNPs with significant p-values were excluded from further analysis.

Information from HapMap where not otherwise indicated.

LB4= leukotriene B4