Table III.
Genotype distributions and age-adjusted odds ratios for significant associations between arachidonic acid metabolism pathway SNPs and prostate cancer risk
| Arachidonic Acid Metabolism Subpathway |
Gene & SNP ID |
Modela | Genotype | No. of Cases/Controls |
Overall Study Population (n= 585 cases; 585 controls) |
Stratified by Obesity | |
|---|---|---|---|---|---|---|---|
| Non-Obese | Obese | ||||||
| OR (95% C.I.) | OR (95% C.I.) | OR (95% C.I.) | |||||
| Leukotriene Synthesis Subpathway | |||||||
| LTA4H rs1978331 | Overdominant | TT + CC | 284/267 | 1.00 | 1.00 | 1.00 | |
| TC | 174/244 | 0.66 (0.50-0.86) | 0.70 (0.52-0.95) | 0.51 (0.29-0.90) | |||
| Unrestricted | TT | 183/175 | 1.00 | ||||
| TC | 174/244 | 0.67 (0.50-0.90) | |||||
| CC | 101/193 | 1.05 (0.73-1.51) | |||||
| Prostaglandin Synthesis Subpathway | |||||||
| PTGES2 rs10987883 | Recessive | AA + AG | 503/526 | 1.00 | 1.00 | 1.00 | |
| GG | 19/10 | 1.52 (0.69-3.35) | 2.53 (0.99-6.55) | 0.17 (0.02-1.57) | |||
| Unrestricted | AA | 384/404 | 1.00 | ||||
| AG | 119/122 | 1.09 (0.81-1.46) | |||||
| GG | 19/10 | 1.55 (0.70-3.42) | |||||
a
The best genetic model for each SNP (bold), as determined by AIC, is provided along with the unrestricted model. Stratified analysis results are only provided for the best genetic models.